Cook the pasta as directed on the package. Add the broccoli to the cooking pasta during the last 3 minutes of cooking. Drain the pasta and broccoli in a strainer and keep warm.
While the pasta is cooking, melt 1/3 cup butter in 4-quart ovenproof saucepan over low heat. Stir in the flour, salt, pepper, and cayenne. Cook and stir for 1 minute. Remove from heat. Gradually stir in the milk and mustard until smooth. Heat to boiling, stirring constantly.
Remove from the heat and then gradually stir in the sour cream and cheeses until melted. Return to low heat and cook until heated through. Stir in the pasta and broccoli.
In a small microwavable bowl, heat the remaining 1 tablespoon butter on High for 20 seconds or until soft and partially melted. Stir in the Panko until coated.
Pour the pasta into an oven-proof casserole dish. Sprinkle the Panko over the pasta. Broil with the top of the casserole dish 6-inches from the heat for 1 to 2 minutes or until the Panko is toasted.